نتایج جستجو برای: benzylpyrazolyl coumarin

تعداد نتایج: 3800  

Multiwalled Carbon Nanotube (MWCNT) reinforced silica aerogel was synthesized in a very simple and cost effective sol - gel method. The process was followed by ambient pressure drying, and then the aerogel material was characterized by XRD, BET, SEM, EDX and FT-IR. 2.3 x 10-3 wt% MWCNTs were successfully incorporated in sodium silicate based silica aerogel. This metal-free nanocomposite catalyz...

Journal: :iranian journal of catalysis 0
mona hosseini-sarvari department of chemistry, shiraz university, shiraz 71454, i.r. iran. sepideh najafvand-derikvandi department of chemistry, shiraz university, shiraz 71454, i.r. iran.

nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  this nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. the prepared sulfated titania s...

Journal: :Molecules 2017
Ana F R Cerqueira Vítor A S Almodôvar Maria G P M S Neves Augusto C Tomé

This review covers the synthesis of coumarin-porphyrin, coumarin-phthalocyanine and coumarin-corrole conjugates and their potential applications. While coumarin-phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin-functionalized phthalonitriles, coumarin-porphyrin and coumarin-corrole conjugates were prepared by complementary approaches: (a) direct synthesis...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1997
S L Born P A Rodriguez C L Eddy L D Lehman-McKeeman

Coumarin is used widely as a fragrance constituent and is administered clinically in the treatment of certain lymphedemas and malignancies. Although toxicity occurs only rarely in humans treated clinically with high-dose coumarin, it is well established that coumarin is hepatotoxic in the rat. This species difference in susceptibility to toxicity reflects the disparate metabolic processes occur...

Dian Ratih Laksmitawati Maesaroh Maesaroh, Moordiani Moordiani, Ni Made Dwi Sandhiutami Nurul Fauziah, Wahyu Widowati,

Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
S L Born J K Hu L D Lehman-McKeeman

o-Hydroxyphenylacetaldehyde (o-HPA), the product of coumarin 3, 4-epoxide, was synthesized and its contribution to the hepatotoxic effects of coumarin in the rat was determined. The relative toxicity of coumarin and o-HPA were initially assessed in Chinese hamster ovary K1 (CHO K1) cells, a cell line that does not contain cytochrome P450. In CHO K1 cells, o-HPA-mediated toxicity greatly exceede...

2013
Archit Garg Darla Mark Manidhar Mahesh Gokara Chandramouli Malleda Cirandur Suresh Reddy Rajagopal Subramanyam

Coumarin is a benzopyrone which is widely used as an anti-coagulant, anti-oxidant, anti-cancer and also to cure arthritis, herpes, asthma and inflammation. Here, we studied the binding of synthesized coumarin derivatives with human serum albumin (HSA) at physiological pH 7.2 by using fluorescence spectroscopy, circular dichroism spectroscopy, molecular docking and molecular dynamics simulation ...

Mona Hosseini-Sarvari, Sepideh Najafvand-Derikvandi

Nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(Trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. Factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  This nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. The prepared sulfated titania s...

Journal: :Molecules and cells 2016
Seeta Poudel Youngseok Lee

Coumarin is a phenolic compound that mainly affects the liver due to its metabolization into a toxic compound. The deterrent and ovicidal activities of coumarin in insect models such as Drosophila melanogaster have been reported. Here we explore the molecular mechanisms by which these insects protect themselves and their eggs from this toxic plant metabolite. Coumarin was fatal to the flies in ...

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